Donald Schreiber MD, CM

Academic Focus or Interests

Dr. Schreiber’s current scholarly work focuses on cardiovascular emergencies and his continuing work with the Multicenter Airway Research Collaboration research group.

Publications

Manini A, Gisondi M, van der Vlugt T, Schreiber DH: Incidence of Cardiac Events after Negative Acute Coronary Syndrome Evaluations. Acad Emerg Med 2002 Sept; 9(9), 896-902.

Lee DL, Herity NA, Hiatt BL, Fearon WF, Rezaee M, Carter AJ, Huston M, Schreiber D, DiBattiste PM, and Yeung AC. Adjunctive Platelet Glycoprotein IIb/IIIa Receptor Inhibition with Tirofiban Before Primary Angioplasty Improves Angiographic Outcomes: Results of the Tirofiban Given in the Emergency Room before Primary Angioplasty (TIGER-PA) Pilot Trial. Circulation, 2003; 107:1497-1501.

Schatz M, Clark S, Emond JA, Schreiber D, Camargo CA: Sex Differences Among Children 2-13 Years Of Age Presenting to the Emergency Department with Acute Asthma. Pediatric Pulmonology. 2004; 37(6): 523-529.

Peer Reviewed Articles

• Blank DW, Nanji AA, Schreiber DH, Hudman C, Sanders HD: Acute Renal Failure and Seizures Associated with Chlorambucil Overdose. Clin Toxicol 20(4): 361-365, 1983.

• Cydulka RK, Emerman CL, Schreiber DH, Molander K, Woodruff PG, Camargo CA: Acute Asthma Among Pregnant Women Presenting to the Emergency Department. Am J Respir Crit Care Med. 1999 Sep; 160(3): 887-92.
• Newby KL, Gibler B, Storrow AB , Garvey JL, Tucker JF, Kaplan AL, Schreiber DH, Ross R, Tuttle RH, McNulty S, Ohman EM: Near-patient, Multi-Marker Strategies for Cardiac Marker Testing Improve Risk Stratification in Chest Pain Units: Results of the CHECKMATE Study. Circulation 2001 April 10; 103(14): 1832-7.
• Schreiber DH . Spinal Cord Injuries. eMedicine Journal [serial online] May 3, 2001; 2(5). Available at: http://www.emedicine.com/emerg/topic553.htm.
• Schreiber DH and Robertson S. Digitalis Toxicity. eMedicine Journal [serial online] May 23, 2001; 2(5). Available at: http://www.emedicine.com/emerg/topic137.htm.
• Schreiber DH : The Role of D-Dimer in the Diagnosis of Venous Thromboembolism. Lab Med 2002; 33(2): 136-144.
• Schreiber DH . Deep Venous Thrombosis and Thrombophlebitis. eMedicine Journal [serial online] 2002; 3(1). Available at: http://www.emedicine.com/emerg/topic122.htm.
• Schreiber DH . Update on Cardiac Markers in the Emergency Department. eMedicine Journal [serial online] 2002; 3(2). Available at: http://www.emedicine.com/emerg/topic932.htm.
• Manini A, Gisondi M, van der Vlugt T, Schreiber DH: Incidence of Cardiac Events after Negative Acute Coronary Syndrome Evaluations. Acad Emerg Med 2002 Sept; 9(9), 896-902.
• Schreiber DH , Pelayo A: Urinalysis, Urine Dipstick and Hematuria in Acute Ureterolithiasis. (Submitted) J Emerg Med October 2002
• Schreiber DH , Passaro D, Barron EJ, Sternbach J, Ryan W, Iyer R, Sternbach G: A Clinical Prediction Rule to Replace the Fecal Leukocyte Stain in Emergency Department Patients with Acute Infectious Diarrhea. (Submitted) J Emerg Med October 2002.
• Lee DL, Herity NA, Hiatt BL, Fearon WF, Rezaee M, Carter AJ, Huston M, Schreiber D, DiBattiste PM, and Yeung AC. Adjunctive Platelet Glycoprotein IIb/IIIa Receptor Inhibition with Tirofiban Before Primary Angioplasty Improves Angiographic Outcomes: Results of the Tirofiban Given in the Emergency Room before Primary Angioplasty (TIGER-PA) Pilot Trial. Circulation, 2003; 107:1497-1501.
• Sánchez CD, Newby LK, Hasselblad V, McNulty SE, Storrow AB, Gibler WB, Garvey JL, Schreiber DH, Tucker JF, Ohman EM: Experience with Diabetic Patients with Suspected Ischemic Heart Disease Assigned to Chest Pain Units: Observations from the CHECKMATE Study. American Journal of Cardiology. May 15, 2003 ; 91: 1228-1230.
• Schatz M, Clark S, Emond JA, Schreiber D, Camargo CA: Sex Differences Among Children 2-13 Years Of Age Presenting to the Emergency Department with Acute Asthma. Pediatric Pulmonology. 2004; 37(6): 523-529.
• Schreiber DH , DeFreest MA: Paroxysmal Atrial Fibrillation Precipitated by Amiodarone Induced Thyrotoxicosis Five Months after Cessation of Therapy. (Submitted Journal of Emergency Medicine, May 2004)
• Schreiber DH , Anderson TA: Statin-Induced Rhabdomyolysis and Hepatitis. (Submitted Journal of Emergency Medicine, May 2004)
• Schreiber DH : Deep Venous Thrombosis and Thrombophlebitis. eMedicine Journal [serial online] June 2004;. Available at: http://www.emedicine.com/emerg/topic122.htm.
• Schreiber DH . Spinal Cord Injuries. eMedicine Journal [serial online] June 2004; Available at: http://www.emedicine.com/emerg/topic553.htm.

Book

Dresser AA, Hazelton RL, Hunt DG, Schreiber DH, Smith TDB, Wilson S: Industrial First Aid: A Reference and Training Manual. Workers’ Compensation Board of British Columbia . 1990.

Book Chapter

Schreiber DH: Venous Disease of the Extremities. In: Rosen P, et al (eds), Emergency Medicine: Concepts and Clinical Practice. 3rd Edition. CV Mosby, 1992. Pages 1451-1487.

Schreiber DH and Robertson, S: Digitalis Toxicity. In: Plantz S, et al(eds), An Electronic Textbook of Emergency Medicine. Boston Scientific, 1998.

Schreiber DH: Deep Venous Thrombosis. In: Plantz S, et al (eds), An Electronic Textbook of Emergency Medicine. Boston Scientific, 1998.

Schreiber DH: Spinal Cord Injuries. In: Plantz S, et al (eds), An Electronic Textbook of Emergency Medicine. Boston Scientific, 1998.

Case Study

Huston M, Schreiber DH, Lee D, Yeung A: Tirofiban in the Setting of Primary Angioplasty Clinical Case Series, Journal of Invasive Cardiology: 1(3) May, 1999 .

Newsletter

Schreiber, DH et al. CORD ECG Database, CORD Newsletter. May/June 2000.

Schreiber, DH. Deep Venous Thrombosis and Thrombophlebitis. Emergency Physicians’ Monthly 8(5), May, 2001. Abstracts: (6 of 22 total)

Newby LK, Storrow AB, Garvey JL, Tucker JF, Kaplan AL, Schreiber DH, Ross CR, Gibler WB, Ohman EM: Earlier and More Effective Risk Stratification in Chest Pain Units Using Near-Patient, Multimarker Testing: Results of the CHECKMATE Study. Circulation 102 (18): II-588, October 31,2000 . Oral Presentation at the AHA 2000 Scientific Sessions, New Orleans , LA. November, 2000.

Newby LK, Storrow AB, Garvey JL, Tucker JF, Kaplan AL, Schreiber DH, Ross CR, Tuttle RH, Gibler WB, Ohman EM: Use of a Near-Patient, Whole Blood, Multi-Marker Strategy (MMS) for Evaluation of Patients with Chest Pain: Results of the Checkmate Study. European Society of Cardiology, Amsterdam , Netherlands . August 2000.

Lee BK, Heidenreich PA, Chun SH, Vagelos RH, Green M, Sussman H, Schreiber DH: Limited Sensitivity of Troponin I for Detecting Acute Myocardial Infarction Six Hours after Chest Pain Onset: The CAMMI Study. Circulation 102 (18): II-497, October 31,2000 . Oral Presentation at the AHA Scientific Sessions, New Orleans , November 2000.

Schreiber DH, Petersen J, Lafayette R, Heidenreich PA: Lack of Prognostic Value for Cardiac Troponin T and I and CKMB in Patients with Chronic Renal Failure on Hemodialysis. Circulation 102 (18): II-520, October 31,2000 . Poster Presentation at the AHA Scientific Sessions, New Orleans , November 2000.

Gisondi, M, Schreiber DH, Manini A, Tan J: High Incidence of Adverse Cardiac Events 6 Months Following Negative Acute Coronary Syndrome Evaluations. Poster presentation at the Society for Academic Emergency Medicine meeting, Atlanta , Georgia . May 2001. Acad Emerg Med 2001: 8: 506.

Schreiber DH, Passaro DJ, Sternbach J, Sternbach G, Barron EJ: A Clinical Prediction Rule to Predict Positive Stool Cultures in ED Patients with Acute Diarrhea. Poster presentation at the Society for Academic Emergency Medicine meeting, Atlanta , Georgia . May 2001. Acad Emerg Med 2001: 8: 478-479.

Invited Presentations

September 2000 “DVT – Update on Diagnosis and Treatment”, Dept of Emergency Medicine, Dominican Community Hospital, Santa Cruz, California .

March 2001 “Cardiac Markers in Acute Coronary Syndromes” Grand Rounds, Dept of Pulmonary and Critical Care Medicine, Palo Alto VA Hospital, Palo Alto CA

April 2001 “Cardiac Markers in the ED” and “Diagnosis and Treatment of DVT”, 7 th Annual Stanford Symposium on Emergency Medicine, Kauai, Hawaii .

April 2001 “An American Perspective on Acute Coronary Syndromes” Honorary Lecture, Section of Emergency Medicine Annual Meeting, British Columbia Medical Association, Vancouver, BC, Canada .

March 2002 “Diagnosis of Pulmonary Embolism” and “Update on Cardiac Markers in the ED”. 8 th Annual Stanford Symposium on Emergency Medicine, Kailua-Kona, Hawaii.

July 2002 “Therapeutic Guidelines for Acute Coronary Syndrome in the Emergency Room” North Bay Emergency Physicians Association Annual Meeting Novato, CA .

January 2003 “Acute Coronary Syndrome” Washoe Health Conference. Squaw Valley , CA

April 2003 “Toxicology for the Intensivist” Grand Rounds, Dept of Pulmonary and Critical Care Medicine, Palo Alto VA Hospital, Palo Alto, CA

April 2004 “Diagnosis of Pulmonary Embolism” “Advanced Airway Workshop” and “Pitfalls with DVT”, 10 th Annual Stanford Symposium on Emergency Medicine, Kauai , Hawaii .

Awards

• April 2001 Honorary Lifetime Membership Award, Section of Emergency Medicine,
• British Columbia Medical Association, Canada (Award for lifetime service to Emergency Medicine)

Memberships in Professional and Learned Societies

• 1980-Present American College of Emergency Physicians
• 1982-Present Canadian Association of Emergency Physicians
• 1982-1994 Canadian Medical Association
• 1983-1994 British Columbia Medical Association (BCMA)
• 1983-Present Section of Emergency Medicine, BCMA
• Secretary-Treasurer 1983-1985
• President-Elect 1985-1987
• President 1987-1989
• Past-President 1989-1991
• 1997-2001 Society of Academic Emergency Medicine

Current Research Activities

Ischemia – Evaluation of a Novel Marker of Myocardial Ischemia, the Cobalt Albumin Binding Test study evaluates the use of a novel marker of myocardial ischemia. Human serum albumin normally is capable of binding cobalt which can then be measured photometrically. In the setting of myocardial ischemia, albumin undergoes an N-terminal transformation that reduces its ability to bind cobalt. An assay has been developed to quantify this change. Preliminary work has shown that this assay is potentially useful in the evaluation of patients with chest pain and myocardial ischemia without infarction. Traditional cardiac markers are sensitive only for myocardial necrosis that occurs during infarction. More commonly, patients suffer from reversible myocardial ischemia without infarction. A multi-center study is currently in progress to further evaluate this new marker, and Dr. Schreiber is the site coordinator for Stanford on this important project. Patients undergoing radionucleotide stress testing to evaluate for myocardial ischemia were prospectively enrolled. Serial blood samples for the cobalt albumin binding assay were collected during their stress test. Test results were then measured using the radionucleotide scan as the gold standard for myocardial ischemia. A cardiac marker of ischemia is potentially significant because it represents the “holy grail” of laboratory medicine- a single blood test with high sensitivity and specificity for myocardial ischemia. Patient enrollment has been completed. Data and statistical analysis is currently in progress.

Recent studies have confirmed the diagnostic value of B-type natriuretic peptide (BNP) a marker of left ventricular strain in congestive heart failure. Earlier work has shown that the level of BNP risk stratifies patients in the ER with acute congestive heart failure. In his Kinetics of BNP in Acute Congestive Heart Failure study, Dr. Schreiber will measure the changes in BNP that occur in the early hours after initiation of therapy for congestive heart failure. He suspects that early responders whose BNP levels fall significantly with therapy are at lower risk for subsequent cardiac events and may be managed in an observation unit or even as an outpatient. Patient enrollment is continuing.

RESCUE ACS study is a prospective open label randomized parallel group investigation to evaluate the efficacy and safety of enoxaparin versus unfractionated heparin in patients who present to the emergency department with acute coronary syndrome. This multi-center study sponsored by Aventis Pharmaceuticals will evaluate the efficacy and safety of enoxaparin, a low molecular weight heparin, administered early in the ER to patients with chest pain at high risk for acute coronary syndrome. Dr. Schreiber is the site coordinator for this study. Patient enrollment has been completed at our site but is continuing at other international sites. Data and statistical analysis will be completed at a future date.

Dr. Schreiber recently initiated the VERITAS-1 Study–Safety and Efficacy Study of Tezosentan in Acute CHF . This is a multi-center study sponsored by Actelion, Inc. evaluating the safety and efficacy of tezosentan, an endothelial receptor antagonist, in the treatment of acute decompensated congestive heart failure (CHF). He is a co-investigator with Dr. Giacomini, Co Chair, Division of Cardiovascular Medicine. Patient enrollment is currently underway.

BNP-CARDS- A study evaluating the safety and efficacy of nesiritide in patients with acute decompensated congestive heart failure and moderate to severe renal insufficiency was recently initiated. Dr. Schreiber is a co-investigator with Drs. Ron Witteles, Michael Fowler and Randy Vagellos from the Division of Cardiovascular Medicine. Dr. Schreiber is the Emergency Department coordinator for the study and will be enrolling patients. The study is currently in progress.

Dr. Schreiber has collaborated with a number of other investigators from the Division of Cardiovascular Medicine led by Dr. Bob Debusk to submit a large NIH grant that proposes to investigate a revolutionary care management model for coronary artery disease. He is a co-PI on the NIH grant request entitled, “A Care Management System for Coronary Artery Disease”, that was submitted on June 1, 2004 It is a 5 year $7.2 million grant request.

Dr. Schreiber’s other area of special interest and expertise is in the area of pulmonary disease. His continues to work as the Stanford and Palo Alto VA site coordinator for the MARC (Multicenter Airway Research Collaboration) Emergency Medicine research effort. The latest study MARC 16 – Clarithromycin in Strep Pneumoniae Community Acquired Pneumonia is a national multicenter study evaluating the efficacy of single dose clarithromycin in outpatient therapy of s. pneumoniae community acquired pneumonia. The study will also evaluate patterns of antibiotic resistance to Streptococcus pneumoniae, one of the bacterial etiologic agents of community acquired pneumonia. In addition, the levels of in-vitro bacterial resistance to clarithromycin will be compared to clinical outcomes. Dr. Schreiber is the site coordinator. He is responsible for enrolling patients and submitting data to the central coordinating center in Boston , MA . Patient enrollment and data collection was completed in February, 2003. Preliminary findings were published (abstract) in Am J Respir Crit Care Med 2003; 167 (7 suppl): A562. and in Acad Emerg Med 2003; 10: 570.) and presented at the Society of Academic Emergency Medicine meeting in May 2003. Further data analysis is in progress and the final report should be published next year.